ÕâÊÇ΢ÄÉÁ¢·½µÚ48ƪ΢Á÷¿ØÍÆÎÄ
24Äê2Ô£¬£¬£¬£¬Luisa BlöbaumµÈÈËÓÚSpringer NatureÆìϵġ¶Microbial Cell Factories¡·ÆÚ¿¯ÉÏ£¬£¬£¬£¬½ÒÏþÁËһƪ¹ØÓÚ¡°ÆÀ¹À΢ÉúÎïÔÚ¿ìËÙת±äµÄÇéÐÎϵÄÌåÏÖºÍÎȹÌÐÔ¡±µÄÐÂÒªÁì¡£¡£¼ò¶øÑÔÖ®£¬£¬£¬£¬×÷ÕßËûÃÇÏëÏàʶµ±Î¢ÉúÎïµÄÉúÑÄÇéÐÎͻȻת±äʱ£¬£¬£¬£¬ËüÃǵÄÉú³¤ËÙÂÊ¡¢ÄÜÁ¿Éú²úµÈÒªº¦¹¦Ð§ÊÇ·ñÄܼá³ÖÎȹ̡£¡£Õâ¹ØÓÚʵÑéÊÒÑо¿ºÍ¹¤ÒµÓ¦Óö¼ºÜÊÇÖ÷Òª£¬£¬£¬£¬ºÃ±ÈÔÚÖÆÒ©»òÄð¾ÆÀú³ÌÖУ¬£¬£¬£¬Ïàʶ΢ÉúÎïÔõÑùÓ¦¶ÔÇéÐÎת±ä¿ÉÒÔ×ÊÖúÌá¸ß²úÁ¿ºÍÖÊÁ¿¡£¡£
×÷Õß½«¶¯Ì¬Î¢Á÷¿Øµ¥Ï¸°û×÷Óý£¨dMSCC£©ºÍ³°ôÐÔÁ¿»¯ÒªÁìÁ¬Ïµ£¬£¬£¬£¬ÕâÔÊÐíËûÃǺÜÊÇ׼ȷµØ¿ØÖƺ͸ıä΢ÉúÎïÖÜΧµÄÇéÐΣ¬£¬£¬£¬Á¬Ïµ»îϸ°û³ÉÏñÊÖÒÕ£¬£¬£¬£¬ÊµÊ±ÊӲ쵥¸öϸ°ûµÄ·´Ó³¡£¡£ÆäÓŵãÊÇËüÄܹ»Ñ¸ËٸıäÌõ¼þ£¬£¬£¬£¬Ä£Äâ×ÔÈ»ÇéÐÎÖжÌʱ¼äÄÚ±¬·¢µÄת±ä£¬£¬£¬£¬²¢ÆÀ¹À΢ÉúÎï¶Ô¼¸Ãë»ò¼¸·ÖÖÓÄÚ±¬·¢×ª±äµÄÐÔÄÜÎȹÌÐÔ¡£¡£
×÷ÕßÒÔÄð¾Æ½ÍĸΪÀý£¬£¬£¬£¬Í¨¹ýÔÚ²î±ðʱ¼ä¾àÀëÄÚ½»ÌæÌṩºÍÏÞÖÆÆÏÌÑÌÇ£¬£¬£¬£¬Ä£ÄâÁË¡°Ê¢ÑçºÍ¼¢¶ö¡±µÄÖÜÆÚ£¬£¬£¬£¬ÊÓ²ì½ÍĸÔõÑùÓ¦¶ÔÕâÖÖ¿ìËÙת±äµÄÇéÐΡ£¡£Ð§¹û·¢Ã÷£¬£¬£¬£¬ËäÈ»½ÍĸµÄÉú³¤ËÙÂÊÓÐËùϽµ£¬£¬£¬£¬µ«ËüÃÇÄܹ»µ÷½â×ÔÉí£¬£¬£¬£¬ÒÔÔöÌíÄÜÁ¿´¢±¸£¨¼´Ï¸°ûÄÚATPˮƽ£©£¬£¬£¬£¬ÓÈÆäÊÇÔڽϳ¤ÖÜÆÚÕðµ´ÖС£¡£È»¶ø£¬£¬£¬£¬ÕâÖÖ˳ӦҲµ¼ÖÂÁ˸öÌå¼ä²î±ðµÄÔöÌí£¬£¬£¬£¬Åú×¢²¢·ÇËùÓÐϸ°û¶¼ÒÔÏàͬµÄ·½Ê½ÏìÓ¦ÇéÐÎת±ä¡£¡£
ͨ¹ýÕâÏîÑо¿£¬£¬£¬£¬×÷Õß¿ª·¢ÁËÒ»ÖÖ°ë×Ô¶¯»¯µÄÆÊÎöÁ÷³Ì£¬£¬£¬£¬²»µ«Äܹ»ÆÀ¹ÀÕû¸öÖÖȺµÄÌåÏÖ£¬£¬£¬£¬»¹ÄÜÏ꾡µ½ÑÇÖÖȺºÍµ¥Ï¸°ûˮƽ¡£¡£ÕâÖÖÒªÁìΪÉîÈëÃ÷ȷ΢ÉúÎïÔõÑùÓ¦¶ÔÇéÐεĿìËÙת±äÌṩÁËǿʢµÄ¹¤¾ß£¬£¬£¬£¬²¢ÇÒ¿ÉÒÔÊÊÓÃÓÚÑо¿ÆäËû΢ÉúÎʹÓòî±ðµÄÉúÎï´«¸ÐÆ÷ºÍ×÷ÓýÌõ¼þ¡£¡£ÕâЩ·¢Ã÷ÓÐÍû×ÊÖúË¢ÐÂ΢ÉúÎï¾úÖêµÄ¿ª·¢ºÍÉúÎ﹤³ÌÀú³Ì£¬£¬£¬£¬Ê¹Æä¸ü¸ßЧ¡¢¸üÎȹ̡£¡£
[1]. Blöbaum L, Torello Pianale L, Olsson L, et al. Quantifying microbial robustness in dynamic environments using microfluidic single-cell cultivation[J]. Microbial Cell Factories, 2024, 23(1): 44.
µØµã£ºhttps://doi.org/10.1186/s12934-024-02318-z
Óõ½µÄ²úÆ·£ºFluigent Flow EZѹÁ¦±Ã¡£¡£
ÔÚÕâÏîÑо¿ÖУ¬£¬£¬£¬Flow EZѹÁ¦±Ãͨ¹ýά³Öº¬ÌÇ×÷Óý»ùµÄѹÁ¦ÔÚ100 mbar£¬£¬£¬£¬Í¬Ê±ÔÚ70ºÍ220 mbarÖ®¼äÇл»À´¿ØÖÆÎÞÌÇ×÷Óý»ùµÄÁ÷¶¯£¬£¬£¬£¬ÊµÏÖÁ˶Ô×÷Óý»ùÁ÷¶¯µÄ׼ȷ¿ØÖÆ¡£¡£²¢Í¨¹ýÉèÖòî±ðµÄÇл»ÆµÂÊ£¨Ã¿1.5¡¢6¡¢12¡¢24ºÍ48·ÖÖÓÒ»´Î£©À´Ñо¿Î¢ÉúÎï¹ØÓÚ²î±ðÉúÎïʱ¼ä±ê×¼ÏÂÇéÐÎת±äµÄÏìÓ¦¡£¡£ÕâЩÉèÖÃËùÓÐͨ¹ýFluigentµÄOxygenÈí¼þ×Ô½ç˵ʵÏÖ¡£¡£